Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo.

Kane, Christopher D; Stevens, Kimberly A; Fischer, James E; Haghpassand, Mehrdad; Royer, Lori J; Aldinger, Charles; Landschulz, Katherine T; Zagouras, Panayiotis; Bagley, Scott W; Hada, William; Dullea, Robert; Hayward, Cheryl M; Francone, Omar L

Kane, Christopher D; Stevens, Kimberly A; Fischer, James E; Haghpassand, Mehrdad; Royer, Lori J; Aldinger, Charles; Landschulz, Katherine T; Zagouras, Panayiotis; Bagley, Scott W; Hada, William; Dullea, Robert; Hayward, Cheryl M; Francone, Omar L.

Affiliation

Kane CD; Departments of Atherosclerosis Biology, Pfizer Global Research & Development, Pfizer Inc, Groton, Connecticut 06340, USA. christopher.d.kane@pfizer.com

Mol Pharmacol ; 75(2): 296-306, 2009 Feb.

Article in En | MEDLINE | ID: mdl-18971326

Subject(s)

Lipid Metabolism/physiology; PPAR alpha/agonists; Piperidines/pharmacology; Animals; Gene Expression Profiling; Humans; Hypolipidemic Agents/pharmacology; Lipid Metabolism/genetics; Liver; Mice; Mice, Transgenic; PPAR alpha/genetics; PPAR alpha/metabolism; Piperidines/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / PPAR alpha / Lipid Metabolism Limits: Animals / Humans Language: En Journal: Mol Pharmacol Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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