Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion.
J Immunol
; 181(10): 6687-91, 2008 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-18981083
ABSTRACT
Chronically SIVagm-infected African green monkeys (AGMs) have a remarkably stable nonpathogenic disease course, with levels of immune activation in chronic SIVagm infection similar to those observed in uninfected monkeys and with stable viral loads for long periods of time. In vivo administration of LPS or an IL-2/diphtheria toxin fusion protein (Ontak) to chronically SIVagm-infected AGMs triggered increases in immune activation and subsequently of viral replication and depletion of intestinal CD4(+) T cells. Our study indicates that circulating microbial products can increase viral replication by inducing immune activation and increasing the number of viral target cells, thus demonstrating that immune activation and T cell proliferation are key factors in AIDS pathogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
CD4-Positive T-Lymphocytes
/
Adjuvants, Immunologic
/
Simian Acquired Immunodeficiency Syndrome
/
Simian Immunodeficiency Virus
Limits:
Animals
Language:
En
Journal:
J Immunol
Year:
2008
Document type:
Article
Affiliation country:
United States