Effects of raloxifene on the urethra of adult castrated female rats.
Climacteric
; 11(6): 483-8, 2008.
Article
in En
| MEDLINE
| ID: mdl-18991075
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the effects of raloxifene on the weight and epithelial thickness of the urethra of castrated female rats.METHODS:
Forty castrated female rats were randomly separated into two groups group I (control, n = 20) received only the vehicle, and group II (raloxifene, n = 20) received 750 microg/day of raloxifene for 30 days. On the 31st day, the animals were sacrificed and the urethras were removed for the study. A model for categorical data using the weighted minimum mean square error method and Student's t test were used for the data analysis (p < 0.05).RESULTS:
The mean weights of the urethras in groups I and II were 22 +/- 1.6 mg and 24 +/- 1.7 mg, respectively (p = 0.371). There was an increase in the mean epithelial thickness of the distal segments in group II compared to group I (50.7 +/- 1.9 microm vs. 45.3 +/- 1.6 microm, respectively) (p < 0.04). No statistically significant difference was found in the mean epithelial thickness of the proximal urethra between the two groups (p = 0.187).CONCLUSION:
Raloxifene administered to castrated female rats for 30 days increased the distal urethral epithelial thickness and did not alter the weight of the urethra.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urethra
/
Urinary Bladder
/
Raloxifene Hydrochloride
/
Selective Estrogen Receptor Modulators
Limits:
Animals
Language:
En
Journal:
Climacteric
Journal subject:
GINECOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Brazil
Country of publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM