Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.

Francis, George J; Martinez, Jose A; Liu, Wei Q; Xu, Kevin; Ayer, Amit; Fine, Jared; Tuor, Ursula I; Glazner, Gordon; Hanson, Leah R; Frey, William H; Toth, Cory

Francis, George J; Martinez, Jose A; Liu, Wei Q; Xu, Kevin; Ayer, Amit; Fine, Jared; Tuor, Ursula I; Glazner, Gordon; Hanson, Leah R; Frey, William H; Toth, Cory.

Affiliation

Francis GJ; Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Brain ; 131(Pt 12): 3311-34, 2008 Dec.

Article in En | MEDLINE | ID: mdl-19015157

Subject(s)

Brain/pathology; Cognition Disorders/prevention & control; Diabetes Mellitus, Experimental/complications; Diabetes Mellitus, Type 1/complications; Insulin/therapeutic use; Administration, Intranasal; Animals; Atrophy/etiology; Atrophy/prevention & control; Cognition Disorders/etiology; Diabetes Mellitus, Experimental/psychology; Diabetes Mellitus, Type 1/psychology; Drug Evaluation, Preclinical/methods; Encephalitis/etiology; Encephalitis/pathology; Encephalitis/prevention & control; Gene Expression Regulation/drug effects; Hippocampus/metabolism; Insulin/administration & dosage; Magnetic Resonance Imaging/methods; Male; Mice; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; RNA, Messenger/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Cognition Disorders / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 / Insulin Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Brain Year: 2008 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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