Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer.
Arch Otolaryngol Head Neck Surg
; 134(11): 1191-5, 2008 Nov.
Article
in En
| MEDLINE
| ID: mdl-19015450
ABSTRACT
OBJECTIVE:
To analyze the ability of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and the fusion of FDG-PET with computed tomography (FDG-PET/CT) to detect synchronous upper gastrointestinal tract (UGI) cancer in newly diagnosed pharyngeal squamous cell carcinoma (SCC). Synchronous UGI cancer is a significant problem in treating pharyngeal SCC, particularly for Japanese populations reported to be at high risk. Good results have been reported from the use of FDG-PET and FDG-PET/CT in staging head and neck SCC (HNSCC). An additional advantage is that both techniques are expected to prove useful in detecting synchronous cancer.DESIGN:
Retrospective analysis of medical records.SETTING:
Aichi Cancer Center, Nagoya, Japan. PATIENTS Forty-three Japanese patients with pharyngeal SCC were assessed for the ability of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer via a comparison with UGI Lugol chromoendoscopy. The patients had undergone 17 FDG-PET and 26 FDG-PET/CT scans before treatment. MAIN OUTCOMEMEASURE:
Sensitivity of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer.RESULTS:
Pathologically, 6 patients with esophageal SCC (14%) and 4 with stomach adenocarcinoma (9%) were diagnosed on the basis of suspect lesions detected by UGI Lugol chromoendoscopy. One patient was found to have stage T2 esophageal cancer by FDG-PET/CT, but no patients had UGI cancer. The sensitivity of detecting T1 UGI cancer by FDG-PET and FDG-PET/CT was 0%.CONCLUSIONS:
The choice of diagnostic technique must be based on the site and histologic characteristics of the synchronous tumor. Although FDG-PET and FDG-PET/CT are still the preferred techniques for staging HNSCC, neither replaces Lugol chromoendoscopy for detecting synchronous UGI cancer in high-risk populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Image Processing, Computer-Assisted
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Esophageal Neoplasms
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Carcinoma, Squamous Cell
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Adenocarcinoma
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Pharyngeal Neoplasms
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Tomography, X-Ray Computed
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Fluorodeoxyglucose F18
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Positron-Emission Tomography
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Neoplasms, Multiple Primary
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Arch Otolaryngol Head Neck Surg
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Japan