In vitro activity of the quinolone WCK 771 against recent U.S. hospital and community-acquired Staphylococcus aureus pathogens with various resistance types.

Bhagwat, Sachin S; McGhee, Pamela; Kosowska-Shick, Klaudia; Patel, Mahesh V; Appelbaum, Peter C

Bhagwat, Sachin S; McGhee, Pamela; Kosowska-Shick, Klaudia; Patel, Mahesh V; Appelbaum, Peter C.

Affiliation

Bhagwat SS; Wockhardt Research Center, Aurangabad, India.

Antimicrob Agents Chemother ; 53(2): 811-3, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19029326

ABSTRACT

ABSTRACT

WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

Subject(s)

Anti-Bacterial Agents/pharmacology; Cross Infection/microbiology; Drug Resistance, Bacterial/drug effects; Fluoroquinolones/pharmacology; Staphylococcal Infections/microbiology; Staphylococcus aureus/drug effects; Cross Infection/epidemiology; Methicillin-Resistant Staphylococcus aureus/drug effects; Microbial Sensitivity Tests; Quinolones/pharmacology; United States/epidemiology; Vancomycin Resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Staphylococcus aureus / Cross Infection / Fluoroquinolones / Drug Resistance, Bacterial / Anti-Bacterial Agents Country/Region as subject: America do norte Language: En Journal: Antimicrob Agents Chemother Year: 2009 Document type: Article Affiliation country: India

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