Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

Horton, Sarah J; Walf-Vorderwülbecke, Vanessa; Chatters, Steve J; Sebire, Neil J; de Boer, Jasper; Williams, Owen

Horton, Sarah J; Walf-Vorderwülbecke, Vanessa; Chatters, Steve J; Sebire, Neil J; de Boer, Jasper; Williams, Owen.

Affiliation

Horton SJ; University College London Institute of Child Health and Great Ormond Street Hospital, United Kingdom.

Blood ; 113(20): 4922-9, 2009 May 14.

Article in En | MEDLINE | ID: mdl-19029444

Subject(s)

Chromosome Aberrations; Genetic Therapy; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/therapy; Myeloid-Lymphoid Leukemia Protein/genetics; Oncogene Proteins, Fusion/antagonists & inhibitors; Animals; Cell Transformation, Neoplastic/genetics; Cells, Cultured; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/genetics; Gene Targeting/methods; Leukemia, Myeloid, Acute/mortality; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein/antagonists & inhibitors; Oncogene Proteins, Fusion/genetics; Remission Induction; Survival Analysis; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Chromosome Aberrations / Myeloid-Lymphoid Leukemia Protein Type of study: Prognostic_studies Limits: Animals Language: En Journal: Blood Year: 2009 Document type: Article Affiliation country: United kingdom Country of publication: United States

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