[Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis].
Zhonghua Kou Qiang Yi Xue Za Zhi
; 43(7): 410-3, 2008 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-19031817
ABSTRACT
OBJECTIVE:
To investigate the relationship between interleukin-6 (IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease.METHODS:
IL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism (PCR-RFLP) method.RESULTS:
IL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P<0.05). -572CC, CG and GG genotype frequency were 52.7 % , 40.9 %, 6.4 % in chronic periodontitis patients and 67.7 %, 31.3%, 1.0 % in control subjects, respectively. -572CG + GG genotype and G allele were more frequent in patients than that in control subjects (P<0.05). Compared with CC genotype,the odds ratio for chronic periodontitis was 1.88 (95% CI 1.04-3.40, P<0.05) for CG + GG genotype.CONCLUSIONS:
The frequency of -572CG + GG genotype was higher in patients with chronic periodontitis compared with the control subjects. IL-6-572C/G polymorphism may be a genetic susceptibility factor for chronic periodontitis in Chinese Hans population.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interleukin-6
/
Polymorphism, Single Nucleotide
/
Chronic Periodontitis
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhonghua Kou Qiang Yi Xue Za Zhi
Journal subject:
ODONTOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
China