Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.

Ho, Tony W; Ferrari, Michel D; Dodick, David W; Galet, Vince; Kost, James; Fan, Xiaoyin; Leibensperger, Heather; Froman, Samar; Assaid, Christopher; Lines, Christopher; Koppen, Hille; Winner, Paul K

Ho, Tony W; Ferrari, Michel D; Dodick, David W; Galet, Vince; Kost, James; Fan, Xiaoyin; Leibensperger, Heather; Froman, Samar; Assaid, Christopher; Lines, Christopher; Koppen, Hille; Winner, Paul K.

Affiliation

Ho TW; Merck Research Laboratories, North Wales, PA 19454-1099, USA. tony_ho@merck.com

Lancet ; 372(9656): 2115-23, 2008 Dec 20.

Article in En | MEDLINE | ID: mdl-19036425

Subject(s)

Azepines/therapeutic use; Calcitonin Gene-Related Peptide Receptor Antagonists; Imidazoles/therapeutic use; Migraine Disorders/drug therapy; Oxazolidinones/therapeutic use; Serotonin Receptor Agonists/therapeutic use; Tryptamines/therapeutic use; Adult; Azepines/adverse effects; Calcitonin Gene-Related Peptide/adverse effects; Calcitonin Gene-Related Peptide/physiology; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Imidazoles/adverse effects; Male; Migraine Disorders/physiopathology; Oxazolidinones/adverse effects; Severity of Illness Index; Tryptamines/adverse effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Tryptamines / Serotonin Receptor Agonists / Oxazolidinones / Calcitonin Gene-Related Peptide Receptor Antagonists / Imidazoles / Migraine Disorders Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: Lancet Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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