The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT): one-year follow-up of a single case.
J Neurol Sci
; 277(1-2): 172-3, 2009 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-19046589
ABSTRACT
In this article, we report the case history of a 44-year-old female patient with bipolar disorder who developed the so-called Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT). A detailed description of our patient's neurologic status is provided at baseline (i.e. during lithium intoxication) and after one year of follow-up, confirming the persistency of cerebellar signs and symptoms. Although rare, our report - which shows a severe and disabling form of SILENT - underscores the need to perform a strict control of the putative risk factors argued to be associated with the development of this syndrome. In our case, the presence of fever and the administration of multiple doses of antipsychotics may have contributed to the poor outcome exhibited by the patient.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Cerebellar Diseases
/
Lithium Compounds
/
Antimanic Agents
/
Neurotoxicity Syndromes
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Neurol Sci
Year:
2009
Document type:
Article
Affiliation country:
Brazil