Tubulin-targeted drug action: functional significance of class ii and class IVb beta-tubulin in vinca alkaloid sensitivity.

Gan, Pei Pei; Kavallaris, Maria

Gan, Pei Pei; Kavallaris, Maria.

Affiliation

Gan PP; Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

Cancer Res ; 68(23): 9817-24, 2008 Dec 01.

Article in En | MEDLINE | ID: mdl-19047161

Subject(s)

Carcinoma, Non-Small-Cell Lung/drug therapy; Lung Neoplasms/drug therapy; Tubulin/metabolism; Vinca Alkaloids/pharmacology; Apoptosis/drug effects; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Division/drug effects; Cell Line, Tumor; Drug Delivery Systems/methods; G2 Phase/drug effects; Humans; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Lung Neoplasms/pathology; Paclitaxel/pharmacokinetics; Paclitaxel/pharmacology; Protein Isoforms; RNA Interference; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Transfection; Tubulin/biosynthesis; Tubulin/deficiency; Tubulin/genetics; Vinblastine/analogs & derivatives; Vinblastine/pharmacokinetics; Vinblastine/pharmacology; Vinca Alkaloids/pharmacokinetics; Vincristine/pharmacokinetics; Vincristine/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tubulin / Vinca Alkaloids / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2008 Document type: Article Affiliation country: Australia Country of publication: United States

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