Early neutropenia is not associated with an increased rate of nosocomial infection in very low-birth-weight infants.
J Perinatol
; 29(3): 219-24, 2009 Mar.
Article
in En
| MEDLINE
| ID: mdl-19078971
ABSTRACT
BACKGROUND:
Evidence is contradictory whether very low-birth-weight (VLBW, birth weight <1500 g) infants with early neutropenia (NP), especially those born to mothers with preeclampsia experience a greater incidence of nosocomial infection (NI).OBJECTIVE:
To investigate whether NP within the first 7 days of life is a risk factor for NI in VLBW infants.METHODS:
Over a 42-month period, we identified all VLBW infants born atRESULTS:
A total of 338 VLBW infants were reviewed. Of those, 51 infants were excluded because of death or onset of an infection before 72 h of age, lack of a complete blood count in the first week of life or treatment with rhG-CSF. Of the remaining 287 infants, NI occurred in 11 of 77 (14.3%) infants with early NP compared to 42 of 210 (20.0%) infants without early NP (P=0.31). Infants who developed NI were smaller and less mature, had lower Apgar scores, were more frequently instrumented with central lines and required a longer duration of parenteral nutrition compared to infants without NI. Infants with NI also had a higher mortality and a greater incidence of necrotizing enterocolitis, severe intraventricular hemorrhage and threshold retinopathy of prematurity. However, using stepwise multivariate logistic regression analysis, only the duration of parenteral nutrition and gestational age were significant risk factors for NI.CONCLUSION:
Our data do not support the hypothesis that early NP increases the risk for NI in VLBW infants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cross Infection
/
Infant, Very Low Birth Weight
/
Infant, Premature, Diseases
/
Neutropenia
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2009
Document type:
Article
Affiliation country:
United States