Unequal representation of different unique genomic DNA sequences in the cell-free plasma DNA of individual donors.
Clin Biochem
; 42(7-8): 736-8, 2009 May.
Article
in En
| MEDLINE
| ID: mdl-19083998
ABSTRACT
OBJECTIVES:
To assess whether different genomic cell-free DNAs are equally abundant in the plasma of individual donors, and any relationship between DNA methylation and representation in plasma. DESIGN ANDMETHODS:
The concentrations of DNA in plasma were determined by real-time PCR.RESULTS:
Different DNA sequences were not equally represented. The relative abundances were similar in different donors.CONCLUSIONS:
Different DNA sequences are not equally abundant in plasma, with no relationship between DNA methylation and abundance.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
Limits:
Humans
Language:
En
Journal:
Clin Biochem
Year:
2009
Document type:
Article
Affiliation country:
United kingdom