Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents.
Neurobiol Aging
; 12(3): 227-31, 1991.
Article
in En
| MEDLINE
| ID: mdl-1908565
ABSTRACT
A severe age-dependent depletion of reduced glutathione (GSH) occurs in rat forebrain at 1-3 h from intraperitoneal injection of the electrophilic agents cyclohexene-1-one and cycloheptene-1-one. Chronic pretreatment with central dopamine agonists (i.e., ergot alkaloids; particularly, dihydroergocriptine) partially counteracts the GSH depletion induced in 15-month-old forebrains by the prooxidants tested. In contrast, chronic pretreatment with a vasodilator agent (i.e., papaverine) magnifies the GSH depletion.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Chemistry
/
Aging
/
Glutathione
Limits:
Animals
Language:
En
Journal:
Neurobiol Aging
Year:
1991
Document type:
Article
Affiliation country:
Italy