4-Hydroxy-2-cyclopentenone: an anti-Pseudomonas and cytotoxic component from Passiflora tetrandra.

Perry, N B; Albertson, G D; Blunt, J W; Cole, A L; Munro, M H; Walker, J R

Perry, N B; Albertson, G D; Blunt, J W; Cole, A L; Munro, M H; Walker, J R.

Affiliation

Perry NB; Department of Chemistry, University of Canterbury, Christchurch, New Zealand.

Planta Med ; 57(2): 129-31, 1991 Apr.

Article in En | MEDLINE | ID: mdl-1909798

ABSTRACT

4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 micrograms/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC50 of less than 1 microgram/ml).

Subject(s)

Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; Cyclopentanes/pharmacology; Plants/analysis; Pseudomonas aeruginosa/drug effects; Animals; Anti-Bacterial Agents/isolation & purification; Antineoplastic Agents, Phytogenic/isolation & purification; Cyclopentanes/isolation & purification; Leukemia P388/drug therapy; Mice; Microbial Sensitivity Tests; Molecular Structure

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Collection: 01-internacional Database: MEDLINE Main subject: Plants / Pseudomonas aeruginosa / Cyclopentanes / Anti-Bacterial Agents / Antineoplastic Agents, Phytogenic Limits: Animals Language: En Journal: Planta Med Year: 1991 Document type: Article Affiliation country: New Zealand Country of publication: Germany

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