Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.

Leedham, Simon J; Graham, Trevor A; Oukrif, Dahmane; McDonald, Stuart A C; Rodriguez-Justo, Manuel; Harrison, Rebecca F; Shepherd, Neil A; Novelli, Marco R; Jankowski, Janusz A Z; Wright, Nicholas A

Leedham, Simon J; Graham, Trevor A; Oukrif, Dahmane; McDonald, Stuart A C; Rodriguez-Justo, Manuel; Harrison, Rebecca F; Shepherd, Neil A; Novelli, Marco R; Jankowski, Janusz A Z; Wright, Nicholas A.

Affiliation

Leedham SJ; Histopathology Unit, Cancer Research UK, London, United Kingdom. simon.leedham@cancer.org.uk

Gastroenterology ; 136(2): 542-50.e6, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19103203

Subject(s)

Colitis, Ulcerative/genetics; Colonic Neoplasms/genetics; Mutation/genetics; Proto-Oncogene Proteins/genetics; Tumor Suppressor Protein p53/genetics; ras Proteins/genetics; Adenomatous Polyposis Coli Protein/genetics; Adenomatous Polyposis Coli Protein/metabolism; Colitis, Ulcerative/complications; Colitis, Ulcerative/metabolism; Colon/metabolism; Colon/pathology; Colonic Neoplasms/etiology; Colonic Neoplasms/metabolism; Genetic Predisposition to Disease/genetics; Humans; Microsatellite Repeats/genetics; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins p21(ras); Tumor Suppressor Protein p53/metabolism; beta Catenin/genetics; beta Catenin/metabolism; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Colonic Neoplasms / Ras Proteins / Mutation Type of study: Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: Gastroenterology Year: 2009 Document type: Article Affiliation country: United kingdom

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