p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice.

Carta, Luca; Smaldone, Silvia; Zilberberg, Lior; Loch, David; Dietz, Harry C; Rifkin, Daniel B; Ramirez, Francesco

Carta, Luca; Smaldone, Silvia; Zilberberg, Lior; Loch, David; Dietz, Harry C; Rifkin, Daniel B; Ramirez, Francesco.

Affiliation

Carta L; Department of Pharmacology and Systems Therapeutics and the Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.

J Biol Chem ; 284(9): 5630-6, 2009 Feb 27.

Article in En | MEDLINE | ID: mdl-19109253

Subject(s)

Aorta, Thoracic/metabolism; Microfilament Proteins/physiology; Signal Transduction; Smad2 Protein/metabolism; Smad3 Protein/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Aorta, Thoracic/cytology; Cells, Cultured; Fibrillin-1; Fibrillins; Gene Expression Regulation, Developmental; Immunoblotting; Immunoenzyme Techniques; MAP Kinase Kinase Kinases/metabolism; Mice; Mice, Knockout; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/metabolism; Phosphorylation; Protein Serine-Threonine Kinases/metabolism; Reactive Oxygen Species; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/metabolism; Smad2 Protein/genetics; Smad3 Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta, Thoracic / Signal Transduction / P38 Mitogen-Activated Protein Kinases / Smad2 Protein / Smad3 Protein / Microfilament Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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