Gene therapy of amyotrophic lateral sclerosis.
Bull Exp Biol Med
; 145(4): 483-6, 2008 Apr.
Article
in En
| MEDLINE
| ID: mdl-19110600
ABSTRACT
Two-year experiments were performed to evaluate the neurotrophic effect of hypoxia-inducible factors (vascular endothelial growth factor and angiogenin) expressed in recombinant human adenoviruses in amyotrophic lateral sclerosis. Randomized placebo-controlled trial demonstrated safety and good tolerability of the recombinant antiviral drugs. The life span of patients under conditions of hypoxia increased after treatment with the test drug, which was probably related to improved resistance of motoneurons. The presence of virus-neutralizing antibodies decreases the effectiveness of adenoviral vectors, which necessitates differential approach to the selection of patients and continuous monitoring of gene therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Genetic Therapy
/
Angiotensinogen
/
Vascular Endothelial Growth Factor A
/
Amyotrophic Lateral Sclerosis
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Bull Exp Biol Med
Year:
2008
Document type:
Article
Affiliation country:
RUSSIA