Etonogestrel implant in women with diabetes mellitus.
Eur J Contracept Reprod Health Care
; 13(4): 387-95, 2008 Dec.
Article
in En
| MEDLINE
| ID: mdl-19117254
ABSTRACT
OBJECTIVES:
To evaluate the effect of etonogestrel implant on the control of the carbohydrate and lipid metabolism and on the progression of vascular complications in diabetic women treated with insulin, and to assess the acceptability of this modality of contraception in these patients.METHODS:
Prospective-observational study of 23 women with insulin-treated diabetes. Clinical and metabolic evaluation was performed before and at 3, 6, 12, and 24 months after implant insertion. Changes from baseline were compared using the mixed effects models or Wilcoxon matched-pairs signed-rank tests.RESULTS:
There were no significant changes in BMI, in daily insulin requirement and in mean HbA1c. There was a significant reduction of total serum cholesterol (TC) at 6 and 12 months, of triglyceride levels at 6, 12 and 24 months, and of high-density lipoprotein cholesterol (HDL-C) at 6, 12 and 24 months. Neither the low-density lipoprotein (LDL) levels nor the HDL/TC ratio changed. Albuminuria decreased significantly at 12 and 24 months. No deterioration of the retina was observed over the study period. Amenorrhoea and infrequent bleeding were the most common menstrual bleeding patterns. One woman discontinued the method due to frequent bleeding.CONCLUSION:
We found no evidence of impaired control of the carbohydrate and lipid metabolism or aggravation of vascular lesions during the two years an etonogestrel implant was used by diabetic women.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Desogestrel
/
Contraceptive Agents, Female
/
Diabetes Mellitus
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Eur J Contracept Reprod Health Care
Journal subject:
MEDICINA REPRODUTIVA
/
SERVICOS DE PLANEJAMENTO FAMILIAR
Year:
2008
Document type:
Article
Affiliation country:
Portugal