Baseline plasma cortisol and ACTH concentrations and response to low-dose ACTH stimulation testing in ill foals.

ABSTRACT

OBJECTIVE: To evaluate baseline plasma cortisol and ACTH concentrations and responses to low-dose ACTH stimulation testing in ill foals. DESIGN: Cross-sectional study. ANIMALS 58 ill foals. PROCEDURES Baseline cortisol and ACTH concentrations and cortisol concentrations after administration of a low dose of cosyntropin were determined within 6 hours after admission. Foals were assigned to 4 groups on the basis of age (septicemia (yes vs no). Values were compared among groups and with values previously reported for healthy foals.

RESULTS:

Plasma cortisol concentrations 30 and 60 minutes after cosyntropin administration in foalscortisol concentrations in older foals. In all 4 groups, plasma cortisol concentration 30 minutes after cosyntropin administration was significantly higher than baseline cortisol concentration or concentration 60 minutes after cosyntropin administration. No differences in baseline cortisol or ACTH concentration or in the ACTH-to-cortisol ratio were detected between groups or when ill foals were compared with healthy foals. A small number of ill foals had low baseline cortisol and ACTH concentrations or low responses to cosyntropin administration, compared with healthy foals. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that most ill foals in the present study population had adequate responses to cosyntropin administration. However, a small subset of ill foals appeared to have dysfunction of the hypothalamic-pituitary-adrenal axis.