Systemic infection of avian influenza A virus H5N1 subtype in humans.
Hum Pathol
; 40(5): 735-9, 2009 May.
Article
in En
| MEDLINE
| ID: mdl-19121843
ABSTRACT
The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Hum Pathol
Journal subject:
PATOLOGIA
Year:
2009
Document type:
Article
Affiliation country:
China