The anti-leukemic effect of a novel histone deacetylase inhibitor MCT-1 and 5-aza-cytidine involves augmentation of Nur77 and inhibition of MMP-9 expression.

Liu, H B; Voso, M T; Gumiero, D; Duong, J; McKendrick, J J; Dear, A E

Liu, H B; Voso, M T; Gumiero, D; Duong, J; McKendrick, J J; Dear, A E.

Affiliation

Liu HB; Australian Centre for Blood Diseases, Eastern Clinical Research Unit, Monash University, and Department of Oncology, Box Hill Hospital, Melbourne, Victoria, Australia.

Int J Oncol ; 34(2): 573-9, 2009 Feb.

Article in En | MEDLINE | ID: mdl-19148494

Subject(s)

Antimetabolites, Antineoplastic/therapeutic use; Azacitidine/therapeutic use; DNA-Binding Proteins/genetics; Histone Deacetylase Inhibitors; Hydroxamic Acids/therapeutic use; Leukemia/drug therapy; Matrix Metalloproteinase 9/genetics; Receptors, Steroid/genetics; Sulfonamides/therapeutic use; Apoptosis/drug effects; Cyclin-Dependent Kinase Inhibitor p15/genetics; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HL-60 Cells/drug effects; Humans; Nuclear Receptor Subfamily 4, Group A, Member 1; RNA, Messenger/genetics; RNA, Neoplasm/genetics; RNA, Neoplasm/isolation & purification; Reverse Transcriptase Polymerase Chain Reaction

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Azacitidine / Leukemia / Receptors, Steroid / Matrix Metalloproteinase 9 / DNA-Binding Proteins / Histone Deacetylase Inhibitors / Hydroxamic Acids / Antimetabolites, Antineoplastic Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2009 Document type: Article Affiliation country: Australia Country of publication: Greece

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