Chronic bilateral dacryo-adenitis in identical twins: a possible incomplete form of Sjögren syndrome.
Eur J Pediatr
; 150(9): 652-5, 1991 Jul.
Article
in En
| MEDLINE
| ID: mdl-1915519
ABSTRACT
We report an unusual case of chronic bilateral dacryo-adenitis in 10-year-old identical twin sisters. Both girls presented with bilateral lacrimal gland enlargement and developed moderate xerophthalmia and keratitis. Both the lacrimal and minor salivary gland biopsies showed a non-granulomatous inflammatory infiltration of mono-nuclear cells. All granulomatous diseases and neoplasms could therefore be ruled out and only Sjögren syndrome and very few other forms of chronic dacryo-adenitis remained as possible diagnoses. Both patients and their parents were evaluated for auto-antibodies. Very low titres of smooth muscle antibodies were found in one, antinuclear antibodies in two and anti-dsDNA antibodies in all four members of the family. Even though the titres of antinuclear and anti-dsDNA antibodies increased in one of the sisters, both patients did not develop any sign or symptom of a systemic connective tissue disease. During the 6 years' follow up, both patients showed persistent tarsal gland enlargement but no other symptoms apart from a moderate xerophthalmia and occasional mild keratitis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sjogren's Syndrome
/
Dacryocystitis
/
Diseases in Twins
Limits:
Child
/
Female
/
Humans
Language:
En
Journal:
Eur J Pediatr
Year:
1991
Document type:
Article