[Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy]. / Unterschenkelulzera bei Sharp-Syndrom. Abheilung unter Sitaxentan.
Z Rheumatol
; 68(2): 154-6, 2009 Mar.
Article
in De
| MEDLINE
| ID: mdl-19156432
ABSTRACT
Leg ulcers may result in serious morbidity in patients with connective tissue diseases and Raynaud's phenomenon (RP). We describe a 35-year-old woman with mixed connective tissue disease who suffered from leg ulcers refractory to iloprost. When the patient was treated with the selective endothelin A receptor antagonist sitaxsentan for pulmonary arterial hypertension, the ulcers improved within 4 weeks and resolved completely thereafter. In addition, severity of RP ameliorated markedly. Further evaluation of sitaxsentan in patients with connective tissue diseases suffering from ischemic skin ulcers is required.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Raynaud Disease
/
Scleroderma, Systemic
/
Thiophenes
/
Isoxazoles
/
Leg Ulcer
Limits:
Adult
/
Female
/
Humans
Language:
De
Journal:
Z Rheumatol
Year:
2009
Document type:
Article