Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors.

Bosker, Fokko J; Folgering, Joost H A; Gladkevich, Anatoliy V; Schmidt, Anne; van der Hart, Marieke C G; Sprouse, Jeffrey; den Boer, Johan A; Westerink, Ben H C; Cremers, Thomas I F H

Bosker, Fokko J; Folgering, Joost H A; Gladkevich, Anatoliy V; Schmidt, Anne; van der Hart, Marieke C G; Sprouse, Jeffrey; den Boer, Johan A; Westerink, Ben H C; Cremers, Thomas I F H.

Affiliation

Bosker FJ; Department of Pharmacy, Biomonitoring & Sensoring, University of Groningen, The Netherlands. f.j.bosker@psy.umcg.nl

J Neurochem ; 108(5): 1126-35, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19166502

Subject(s)

Action Potentials/drug effects; Neurons/drug effects; Receptors, Serotonin/physiology; Serotonin Agents/pharmacology; Serotonin/metabolism; Action Potentials/physiology; Analysis of Variance; Animals; Brain/cytology; Chromatography, High Pressure Liquid/methods; Citalopram/pharmacology; Drug Interactions; Electrochemistry/methods; Male; Microdialysis/methods; Neurons/physiology; Piperazines/pharmacology; Piperidines/pharmacology; Pyrazoles/pharmacology; Pyridines/pharmacology; Pyrrolidines/pharmacology; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A/physiology; Serotonin 5-HT1 Receptor Antagonists; Selective Serotonin Reuptake Inhibitors/pharmacology; Tetrahydronaphthalenes/pharmacology; Tosyl Compounds/pharmacology; Wakefulness

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Action Potentials / Serotonin / Receptors, Serotonin / Serotonin Agents / Neurons Limits: Animals Language: En Journal: J Neurochem Year: 2009 Document type: Article Affiliation country: Netherlands Country of publication: United kingdom

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