Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Bioorg Med Chem Lett
; 19(4): 1071-4, 2009 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-19171483
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylethanolamine N-Methyltransferase
/
Tetrahydroisoquinolines
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2009
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom