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Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Wu, Qian; Caine, Joanne M; Thomson, Stuart A; Slavica, Meri; Grunewald, Gary L; McLeish, Michael J.
Affiliation
  • Wu Q; College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
Bioorg Med Chem Lett ; 19(4): 1071-4, 2009 Feb 15.
Article in En | MEDLINE | ID: mdl-19171483
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylethanolamine N-Methyltransferase / Tetrahydroisoquinolines Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylethanolamine N-Methyltransferase / Tetrahydroisoquinolines Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom