Control of ER stress by a chemical chaperone counteracts apoptotic signals in IFN-gamma-treated murine hepatocytes.

Kanki, Keita; Kawamura, Takeshi; Watanabe, Yoshifumi

Kanki, Keita; Kawamura, Takeshi; Watanabe, Yoshifumi.

Affiliation

Kanki K; Department of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo, Tokyo, Japan.

Apoptosis ; 14(3): 309-19, 2009 Mar.

Article in En | MEDLINE | ID: mdl-19184438

Subject(s)

Apoptosis/physiology; Endoplasmic Reticulum/metabolism; Hepatocytes/metabolism; Interferon-gamma/pharmacology; Animals; Apoptosis/drug effects; Caspases/drug effects; Caspases/metabolism; Cells, Cultured; Cytochromes c/metabolism; DNA Fragmentation/drug effects; Endoplasmic Reticulum/drug effects; Female; Glycerol/pharmacology; Hepatocytes/drug effects; Interferon Regulatory Factor-1/drug effects; Interferon Regulatory Factor-1/metabolism; Mice; Mice, Inbred ICR; Molecular Chaperones/pharmacology; Reactive Oxygen Species/metabolism; Recombinant Proteins; Signal Transduction/drug effects; Signal Transduction/physiology; Transcription Factor CHOP/drug effects; Transcription Factor CHOP/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon-gamma / Apoptosis / Hepatocytes / Endoplasmic Reticulum Type of study: Prognostic_studies Limits: Animals Language: En Journal: Apoptosis Year: 2009 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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