Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein.

Reed, Mark L; Yen, Hui-Ling; DuBois, Rebecca M; Bridges, Olga A; Salomon, Rachelle; Webster, Robert G; Russell, Charles J

Reed, Mark L; Yen, Hui-Ling; DuBois, Rebecca M; Bridges, Olga A; Salomon, Rachelle; Webster, Robert G; Russell, Charles J.

Affiliation

Reed ML; Department of Infectious Diseases, MS 330, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

J Virol ; 83(8): 3568-80, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19193808

Subject(s)

Hemagglutinin Glycoproteins, Influenza Virus/genetics; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Influenza A Virus, H5N1 Subtype/physiology; Virus Internalization; Amino Acid Substitution/genetics; Animals; Cell Line; Chlorocebus aethiops; Cricetinae; DNA Mutational Analysis; Hydrogen-Ion Concentration; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Point Mutation; Protein Structure, Tertiary; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hemagglutinin Glycoproteins, Influenza Virus / Influenza A Virus, H5N1 Subtype / Virus Internalization Limits: Animals Language: En Journal: J Virol Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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