Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis.

Chia, Ian V; Kim, Min Jung; Itoh, Keiji; Sokol, Sergei Y; Costantini, Frank

Chia, Ian V; Kim, Min Jung; Itoh, Keiji; Sokol, Sergei Y; Costantini, Frank.

Affiliation

Chia IV; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.

Genetics ; 181(4): 1359-68, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19204372

Subject(s)

Embryonic Development/genetics; Repressor Proteins/chemistry; Repressor Proteins/physiology; Amino Acid Motifs/genetics; Amino Acid Motifs/physiology; Animals; Animals, Genetically Modified; Axin Protein; Base Sequence; Cells, Cultured; Embryo, Mammalian; Embryo, Nonmammalian; Fetal Viability/genetics; Gene Deletion; Genes, Lethal; Mice; Molecular Sequence Data; Mutant Proteins/physiology; Protein Structure, Tertiary/genetics; Protein Structure, Tertiary/physiology; RGS Proteins/chemistry; RGS Proteins/genetics; Repressor Proteins/genetics; Wnt Proteins/physiology; Xenopus/embryology; Xenopus Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Embryonic Development Type of study: Prognostic_studies Limits: Animals Language: En Journal: Genetics Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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