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Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone, Massimiliano; Dettori, Daniela; de Oliveira, Rodrigo Leite; Loges, Sonja; Schmidt, Thomas; Jonckx, Bart; Tian, Ya-Min; Lanahan, Anthony A; Pollard, Patrick; de Almodovar, Carmen Ruiz; De Smet, Frederik; Vinckier, Stefan; Aragonés, Julián; Debackere, Koen; Luttun, Aernout; Wyns, Sabine; Jordan, Benedicte; Pisacane, Alberto; Gallez, Bernard; Lampugnani, Maria Grazia; Dejana, Elisabetta; Simons, Michael; Ratcliffe, Peter; Maxwell, Patrick; Carmeliet, Peter.
Affiliation
  • Mazzone M; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Dettori D; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • de Oliveira RL; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Loges S; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Schmidt T; Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, 10060 Candiolo, Turin, Italy.
  • Jonckx B; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Tian YM; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Lanahan AA; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Pollard P; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • de Almodovar CR; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • De Smet F; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Vinckier S; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Aragonés J; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Debackere K; The Henry Wellcome Building of Genomic Medicine, Oxford OX3 7BN, UK.
  • Luttun A; Cardiovascular Medicine, Yale University, New Haven, CT 06510, USA.
  • Wyns S; The Henry Wellcome Building of Genomic Medicine, Oxford OX3 7BN, UK.
  • Jordan B; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Pisacane A; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Gallez B; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Lampugnani MG; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Dejana E; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Simons M; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Ratcliffe P; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
  • Maxwell P; Vesalius Research Center, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
  • Carmeliet P; Vesalius Research Center, VIB-Vlaams Instituut voor Biotechnologie, 3000 Leuven, Belgium.
Cell ; 136(5): 839-851, 2009 Mar 06.
Article in En | MEDLINE | ID: mdl-19217150
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Blood Vessels / Immediate-Early Proteins / Endothelial Cells / DNA-Binding Proteins / Neoplasm Metastasis / Neoplasms Limits: Animals Language: En Journal: Cell Year: 2009 Document type: Article Affiliation country: Belgium Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Blood Vessels / Immediate-Early Proteins / Endothelial Cells / DNA-Binding Proteins / Neoplasm Metastasis / Neoplasms Limits: Animals Language: En Journal: Cell Year: 2009 Document type: Article Affiliation country: Belgium Country of publication: United States