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Phytochelatins inhibit the metal-induced aggregation of alpha-crystallin.
Hori, Yasuhisa; Yoshikawa, Tomoaki; Tsuji, Naoki; Bamba, Takeshi; Aso, Yoshikazu; Kudou, Motonori; Uchida, Yoshiki; Takagi, Masahiro; Harada, Kazuo; Hirata, Kazumasa.
Affiliation
  • Hori Y; Department of Environmental Biotechnology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. hori@phs.osaka-u.ac.jp
J Biosci Bioeng ; 107(2): 173-6, 2009 Feb.
Article in En | MEDLINE | ID: mdl-19217556
ABSTRACT
Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced alpha-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-Crystallins / Phytochelatins / Metals Language: En Journal: J Biosci Bioeng Journal subject: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Year: 2009 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha-Crystallins / Phytochelatins / Metals Language: En Journal: J Biosci Bioeng Journal subject: ENGENHARIA BIOMEDICA / MICROBIOLOGIA Year: 2009 Document type: Article Affiliation country: Japan