Follicular helper T cells are required for systemic autoimmunity.

Linterman, Michelle A; Rigby, Robert J; Wong, Raphael K; Yu, Di; Brink, Robert; Cannons, Jennifer L; Schwartzberg, Pamela L; Cook, Matthew C; Walters, Giles D; Vinuesa, Carola G

Linterman, Michelle A; Rigby, Robert J; Wong, Raphael K; Yu, Di; Brink, Robert; Cannons, Jennifer L; Schwartzberg, Pamela L; Cook, Matthew C; Walters, Giles D; Vinuesa, Carola G.

Affiliation

Linterman MA; Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

J Exp Med ; 206(3): 561-76, 2009 Mar 16.

Article in En | MEDLINE | ID: mdl-19221396

Subject(s)

Autoimmunity/immunology; Germinal Center/cytology; T-Lymphocytes, Helper-Inducer/immunology; Animals; Antigens, Differentiation, T-Lymphocyte/metabolism; Autoantibodies/blood; B-Lymphocytes/cytology; B-Lymphocytes/immunology; CD28 Antigens/metabolism; Cell Count; Cell Proliferation; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/metabolism; Germinal Center/immunology; Heterozygote; Inducible T-Cell Co-Stimulator Protein; Interleukins/deficiency; Lupus Erythematosus, Systemic/blood; Lupus Erythematosus, Systemic/immunology; Lupus Erythematosus, Systemic/pathology; Lymphocyte Activation; Lymphocyte Subsets/cytology; Lymphocyte Subsets/immunology; Mice; Phenotype; Proto-Oncogene Proteins c-bcl-6; T-Lymphocytes, Helper-Inducer/transplantation; Th1 Cells/cytology; Th1 Cells/immunology; Th2 Cells/cytology; Th2 Cells/immunology; Ubiquitin-Protein Ligases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmunity / T-Lymphocytes, Helper-Inducer / Germinal Center Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Exp Med Year: 2009 Document type: Article Affiliation country: Australia

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