Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner.

Schayek, Hagit; Haugk, Kathy; Sun, Shihua; True, Lawrence D; Plymate, Stephen R; Werner, Haim

Schayek, Hagit; Haugk, Kathy; Sun, Shihua; True, Lawrence D; Plymate, Stephen R; Werner, Haim.

Affiliation

Schayek H; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Clin Cancer Res ; 15(5): 1558-65, 2009 Mar 01.

Article in En | MEDLINE | ID: mdl-19223505

Subject(s)

BRCA1 Protein/metabolism; Gene Expression Regulation, Neoplastic; Prostatic Neoplasms/genetics; Receptor, IGF Type 1/genetics; Receptors, Androgen/metabolism; Transcription, Genetic; Aged; Animals; BRCA1 Protein/genetics; Blotting, Western; Cell Proliferation; Humans; Male; Mice; Mice, Nude; Middle Aged; Promoter Regions, Genetic; Prostate/metabolism; Prostate/pathology; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Receptor, IGF Type 1/metabolism; Receptors, Androgen/genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Transcription, Genetic / Receptors, Androgen / Gene Expression Regulation, Neoplastic / Receptor, IGF Type 1 / BRCA1 Protein Limits: Aged / Animals / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2009 Document type: Article Affiliation country: Israel Country of publication: United States

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