Identification of a polymorphism in the RING finger of human Bmi-1 that causes its degradation by the ubiquitin-proteasome system.

Zhang, Jie; Sarge, Kevin D

Zhang, Jie; Sarge, Kevin D.

Affiliation

Zhang J; Graduate Center for Toxicology, Chandler Medical Center, University of Kentucky, Lexington, KY 40536, USA.

FEBS Lett ; 583(6): 960-4, 2009 Mar 18.

Article in En | MEDLINE | ID: mdl-19233177

Subject(s)

Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; RING Finger Domains/genetics; Repressor Proteins/genetics; Repressor Proteins/metabolism; Amino Acid Sequence; Cells, Cultured; Cysteine/genetics; Cysteine/metabolism; Cysteine Proteinase Inhibitors/pharmacology; Humans; Leupeptins/pharmacology; Nuclear Proteins/chemistry; Polycomb Repressive Complex 1; Polymorphism, Single Nucleotide/physiology; Protein Denaturation/genetics; Protein Processing, Post-Translational/drug effects; Protein Processing, Post-Translational/genetics; Proto-Oncogene Proteins/chemistry; Repressor Proteins/chemistry; Transfection; Tyrosine/genetics; Ubiquitin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Nuclear Proteins / Proto-Oncogene Proteins / Polymorphism, Single Nucleotide / Proteasome Endopeptidase Complex / RING Finger Domains Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: FEBS Lett Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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