Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists.

Sato, Nagaaki; Jitsuoka, Makoto; Ishikawa, Shiho; Nagai, Keita; Tsuge, Hiroyasu; Ando, Makoto; Okamoto, Osamu; Iwaasa, Hisashi; Gomori, Akira; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro

Sato, Nagaaki; Jitsuoka, Makoto; Ishikawa, Shiho; Nagai, Keita; Tsuge, Hiroyasu; Ando, Makoto; Okamoto, Osamu; Iwaasa, Hisashi; Gomori, Akira; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro.

Affiliation

Sato N; Tsukuba Research Institute, Merck Research Laboratories, Banyu Pharmaceutical Company, Ltd, 3 Okubo, Tsukuba 300-2611, Japan.

Bioorg Med Chem Lett ; 19(6): 1670-4, 2009 Mar 15.

Article in En | MEDLINE | ID: mdl-19233647

Subject(s)

Chemistry, Pharmaceutical/methods; Imidazoles/chemistry; Receptors, Neuropeptide Y/chemistry; Animals; Brain/metabolism; Carboxylic Acids/chemistry; Cerebrospinal Fluid/metabolism; Drug Design; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Structure; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemistry, Pharmaceutical / Receptors, Neuropeptide Y / Imidazoles Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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