IL-6 loss causes ventricular dysfunction, fibrosis, reduced capillary density, and dramatically alters the cell populations of the developing and adult heart.

Banerjee, Indroneal; Fuseler, John W; Intwala, Arti R; Baudino, Troy A

Banerjee, Indroneal; Fuseler, John W; Intwala, Arti R; Baudino, Troy A.

Affiliation

Banerjee I; Department of Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Am J Physiol Heart Circ Physiol ; 296(5): H1694-704, 2009 May.

Article in En | MEDLINE | ID: mdl-19234091

Subject(s)

Cell Communication; Fibroblasts/metabolism; Heart/growth & development; Interleukin-6/metabolism; Myocytes, Cardiac/metabolism; Neovascularization, Physiologic; Ventricular Dysfunction/metabolism; Age Factors; Aging; Animals; Animals, Newborn; Apoptosis; Capillaries/metabolism; Capillaries/physiopathology; Cell Adhesion Molecules/metabolism; Cell Proliferation; Cells, Cultured; Collagen/metabolism; Fibroblasts/pathology; Fibrosis; Interleukin-6/deficiency; Interleukin-6/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac/pathology; STAT3 Transcription Factor/metabolism; Signal Transduction; Vascular Endothelial Growth Factor A/metabolism; Ventricular Dysfunction/pathology; Ventricular Dysfunction/physiopathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Communication / Interleukin-6 / Ventricular Dysfunction / Neovascularization, Physiologic / Myocytes, Cardiac / Fibroblasts / Heart Type of study: Etiology_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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