Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.
Nat Neurosci
; 12(3): 247-9, 2009 Mar.
Article
in En
| MEDLINE
| ID: mdl-19234455
ABSTRACT
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress, Psychological
/
Dopamine
/
Receptors, Glucocorticoid
/
Behavior, Addictive
/
Cocaine
/
Neurons
Limits:
Animals
Language:
En
Journal:
Nat Neurosci
Journal subject:
NEUROLOGIA
Year:
2009
Document type:
Article
Affiliation country:
France