Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.

Beumer, J H; Franke, N E; Tolboom, R; Buckle, T; Rosing, H; Lopez-Lazaro, L; Schellens, J H M; Beijnen, J H; van Tellingen, O

Beumer, J H; Franke, N E; Tolboom, R; Buckle, T; Rosing, H; Lopez-Lazaro, L; Schellens, J H M; Beijnen, J H; van Tellingen, O.

Affiliation

Beumer JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. beumerjh@upmc.edu

Invest New Drugs ; 28(2): 145-55, 2010 Apr.

Article in En | MEDLINE | ID: mdl-19238326

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/deficiency; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Dioxoles/pharmacokinetics; Dioxoles/toxicity; Tetrahydroisoquinolines/pharmacokinetics; Tetrahydroisoquinolines/toxicity; Animals; Area Under Curve; Dioxoles/chemistry; Dioxoles/metabolism; Dose-Response Relationship, Drug; Female; Liver/drug effects; Liver/enzymology; Liver/pathology; Male; Maximum Tolerated Dose; Mice; Mice, Knockout; Tetrahydroisoquinolines/chemistry; Tetrahydroisoquinolines/metabolism; Tissue Distribution/drug effects; Trabectedin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: ATP Binding Cassette Transporter, Subfamily B, Member 1 / Tetrahydroisoquinolines / Dioxoles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Invest New Drugs Year: 2010 Document type: Article Affiliation country: Netherlands Country of publication: United States

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