[An experimental study on pulmonary toxicity water extracts of Siegesbeckia pubescens on mice].
Zhongguo Zhong Yao Za Zhi
; 33(23): 2820-2, 2008 Dec.
Article
in Zh
| MEDLINE
| ID: mdl-19260321
ABSTRACT
OBJECTIVE:
The pulmonary toxicity of water extract of Siegesbeckia pubescens has been studied an mice following subchronic oral administration route.METHOD:
Mice were randomly grouped and administered with the water extract of S. pubescens at dosages of 3.0, 1.0, 0.3 g x kg(-1) and saline respectively. 10 mice of each group were sacrificed on the day of 7 th, 14 th, 21 th, and 2 weeks after stopping administration, histological changes of the lung were examined.RESULT:
The water extract of S. pubescens at dosage of 3.0 g x kg(-1) increased the lung index on the of day 14 th and 21 th, significant histopathological damages were observed. The histopathological changes were disappeared after stopping administration for 2 weeks.CONCLUSION:
The water extract of S. pubescens has a pulmonary toxic effect on mice, and the toxic effect is reversible.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
Asteraceae
/
Lung
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Journal subject:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Year:
2008
Document type:
Article
Affiliation country:
China
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA