Collaborative work on evaluation of ovarian toxicity. 11) Two- or four-week repeated-dose studies and fertility study of ethylene glycol monomethyl ether in female rats.

Dodo, Tetsushi; Taketa, Yoshikazu; Sugiyama, Mayumi; Inomata, Akira; Sonoda, Jiro; Okuda, Yasuyuki; Mineshima, Hiroshi; Hosokawa, Satoru; Aoki, Toyohiko

Dodo, Tetsushi; Taketa, Yoshikazu; Sugiyama, Mayumi; Inomata, Akira; Sonoda, Jiro; Okuda, Yasuyuki; Mineshima, Hiroshi; Hosokawa, Satoru; Aoki, Toyohiko.

Affiliation

Dodo T; Drug Safety Research Laboratories (Kakamigahara), Eisai Co., Ltd., Kakamigahara-shi, Gifu, Japan. t-dodo@hhc.eisai.co.jp

J Toxicol Sci ; 34 Suppl 1: SP121-8, 2009.

Article in En | MEDLINE | ID: mdl-19265278

Subject(s)

Ethylene Glycols/toxicity; Fertility/drug effects; Ovary/drug effects; Solvents/toxicity; Toxicity Tests/methods; Animals; Apoptosis/drug effects; Biomarkers/metabolism; Corpus Luteum/drug effects; Corpus Luteum/pathology; Drug Administration Schedule; Embryo Loss/chemically induced; Embryo, Mammalian/drug effects; Embryonic Development/drug effects; Estrous Cycle/drug effects; Ethylene Glycols/administration & dosage; Female; Japan; Male; Ovarian Follicle/drug effects; Ovarian Follicle/metabolism; Ovarian Follicle/pathology; Ovary/pathology; Ovulation/drug effects; Pregnancy; Proliferating Cell Nuclear Antigen/metabolism; Public-Private Sector Partnerships; Rats; Rats, Sprague-Dawley; Societies, Scientific; Solvents/administration & dosage; Weight Gain/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Ovary / Solvents / Toxicity Tests / Ethylene Glycols / Fertility Limits: Animals / Pregnancy Country/Region as subject: Asia Language: En Journal: J Toxicol Sci Year: 2009 Document type: Article Affiliation country: Japan Country of publication: Japan

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