Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep.
Am J Trop Med Hyg
; 80(3): 367-72, 2009 Mar.
Article
in En
| MEDLINE
| ID: mdl-19270283
ABSTRACT
Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5x2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sheep Diseases
/
Thiazoles
/
Benzimidazoles
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Echinococcosis, Hepatic
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Echinococcosis, Pulmonary
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Antiparasitic Agents
Limits:
Animals
Language:
En
Journal:
Am J Trop Med Hyg
Year:
2009
Document type:
Article
Affiliation country:
Peru
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA