Nonreplicating vaccinia virus vectors expressing the H5 influenza virus hemagglutinin produced in modified Vero cells induce robust protection.

Mayrhofer, Josef; Coulibaly, Sogue; Hessel, Annett; Holzer, Georg W; Schwendinger, Michael; Brühl, Peter; Gerencer, Marijan; Crowe, Brian A; Shuo, Shen; Hong, Wanjing; Tan, Yee Joo; Dietrich, Barbara; Sabarth, Nicolas; Savidis-Dacho, Helga; Kistner, Otfried; Barrett, P Noel; Falkner, Falko G

Mayrhofer, Josef; Coulibaly, Sogue; Hessel, Annett; Holzer, Georg W; Schwendinger, Michael; Brühl, Peter; Gerencer, Marijan; Crowe, Brian A; Shuo, Shen; Hong, Wanjing; Tan, Yee Joo; Dietrich, Barbara; Sabarth, Nicolas; Savidis-Dacho, Helga; Kistner, Otfried; Barrett, P Noel; Falkner, Falko G.

Affiliation

Mayrhofer J; Baxter Bioscience, Biomedical Research Center, Uferstrasse 15, A-2304 Orth/Donau, Austria.

J Virol ; 83(10): 5192-203, 2009 May.

Article in En | MEDLINE | ID: mdl-19279103

Subject(s)

Genetic Vectors; Hemagglutinin Glycoproteins, Influenza Virus/immunology; Influenza A Virus, H5N1 Subtype/immunology; Influenza Vaccines/immunology; Orthomyxoviridae Infections/prevention & control; Animals; Antibodies, Viral/immunology; CD8-Positive T-Lymphocytes/immunology; Chlorocebus aethiops; Defective Viruses/genetics; Female; Influenza A Virus, H5N1 Subtype/genetics; Interferon-gamma/analysis; Mice; Mice, Inbred BALB C; Mice, Nude; Orthomyxoviridae Infections/immunology; Vaccinia virus/genetics; Vero Cells; Virus Cultivation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza Vaccines / Orthomyxoviridae Infections / Hemagglutinin Glycoproteins, Influenza Virus / Influenza A Virus, H5N1 Subtype / Genetic Vectors Limits: Animals Language: En Journal: J Virol Year: 2009 Document type: Article Affiliation country: Austria Country of publication: United States

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