Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.
Biochem Biophys Res Commun
; 382(3): 561-5, 2009 May 08.
Article
in En
| MEDLINE
| ID: mdl-19292977
ABSTRACT
Chronic pancreatitis increases by 16-fold the risk of developing pancreatic ductal adenocarcinoma (PDAC), one of the deadliest human cancers. It also appears to accelerate cancer progression in genetically engineered mouse models. We now report that in a mouse model where oncogenic Kras is activated in all pancreatic cell types, two brief episodes of acute pancreatitis caused rapid PanIN progression and accelerated pancreatic cancer development. Thus, a brief inflammatory insult to the pancreas, when occurring in the context of oncogenic Kras(G12D), can initiate a cascade of events that dramatically enhances the risk for pancreatic malignant transformation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
/
Pancreatitis
/
Cell Transformation, Neoplastic
/
Proto-Oncogene Proteins p21(ras)
Limits:
Animals
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2009
Document type:
Article
Affiliation country:
United States