Aspartic Acid/analogs & derivatives; Canavan Disease/metabolism; Cerebral Cortex/metabolism; Neurotoxins/toxicity; Oxidative Stress/physiology; Animals; Antioxidants/metabolism; Aspartic Acid/administration & dosage; Aspartic Acid/metabolism; Aspartic Acid/toxicity; Brain Damage, Chronic/etiology; Brain Damage, Chronic/metabolism; Canavan Disease/complications; Catalase/drug effects; Catalase/metabolism; Cerebral Cortex/drug effects; Dipeptides/administration & dosage; Dipeptides/metabolism; Dipeptides/toxicity; Disease Models, Animal; Glucosephosphate Dehydrogenase/drug effects; Glucosephosphate Dehydrogenase/metabolism; Glutathione Peroxidase/drug effects; Glutathione Peroxidase/metabolism; Injections, Intraventricular; Lipid Peroxidation; Male; Neuropeptides/administration & dosage; Neuropeptides/metabolism; Neuropeptides/toxicity; Neurotoxins/administration & dosage; Neurotoxins/metabolism; Oxidation-Reduction; Oxidative Stress/drug effects; Rats; Rats, Wistar