Your browser doesn't support javascript.
loading
Fragment-based identification of Hsp90 inhibitors.
Barker, John J; Barker, Oliver; Boggio, Roberto; Chauhan, Viddhata; Cheng, Robert K Y; Corden, Vincent; Courtney, Stephen M; Edwards, Neil; Falque, Virginie M; Fusar, Fulvia; Gardiner, Mihaly; Hamelin, Estelle M N; Hesterkamp, Thomas; Ichihara, Osamu; Jones, Richard S; Mather, Owen; Mercurio, Ciro; Minucci, Saverio; Montalbetti, Christian A G N; Müller, Annett; Patel, Deepti; Phillips, Banu G; Varasi, Mario; Whittaker, Mark; Winkler, Dirk; Yarnold, Christopher J.
Affiliation
  • Barker JJ; Evotec, 114 Milton Park, Abingdon, Oxfordshire, OX10 4SA UK.
ChemMedChem ; 4(6): 963-6, 2009 Jun.
Article in En | MEDLINE | ID: mdl-19301319
ABSTRACT
Heat shock protein 90 (Hsp90) plays a key role in stress response and protection of the cell against the effects of mutation. Herein we report the identification of an Hsp90 inhibitor identified by fragment screening using a high-concentration biochemical assay, as well as its optimisation by in silico searching coupled with a structure-based drug design (SBDD) approach.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Pyrimidines / HSP90 Heat-Shock Proteins Type of study: Diagnostic_studies Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2009 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Pyrimidines / HSP90 Heat-Shock Proteins Type of study: Diagnostic_studies Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2009 Document type: Article