A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients.

Ghassabian, Sussan; Chetty, Manoranjenni; Tattam, Bruce N; Chem, Mraci C; Glen, John; Rahme, Jeannie; Stankovic, Zvijezdana; Ramzan, Iqbal; Murray, Michael; McLachlan, Andrew J

Ghassabian, Sussan; Chetty, Manoranjenni; Tattam, Bruce N; Chem, Mraci C; Glen, John; Rahme, Jeannie; Stankovic, Zvijezdana; Ramzan, Iqbal; Murray, Michael; McLachlan, Andrew J.

Affiliation

Ghassabian S; Faculty of Pharmacy, University of Sydney, Camperdown, New South Wales, Australia.

Ther Drug Monit ; 31(2): 239-46, 2009 Apr.

Article in En | MEDLINE | ID: mdl-19307938

Subject(s)

Cytochrome P-450 Enzyme System/genetics; Biotransformation; Caffeine/pharmacokinetics; Chromatography, Liquid; Dextromethorphan/pharmacokinetics; Humans; Losartan/pharmacokinetics; Midazolam/pharmacokinetics; Omeprazole/pharmacokinetics; Phenotype; Tandem Mass Spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 Enzyme System Limits: Humans Language: En Journal: Ther Drug Monit Year: 2009 Document type: Article Affiliation country: Australia

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