Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells.

López-Albaitero, Andrés; Lee, Steve C; Morgan, Sarah; Grandis, Jennifer R; Gooding, William E; Ferrone, Soldano; Ferris, Robert L

López-Albaitero, Andrés; Lee, Steve C; Morgan, Sarah; Grandis, Jennifer R; Gooding, William E; Ferrone, Soldano; Ferris, Robert L.

Affiliation

López-Albaitero A; Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

Cancer Immunol Immunother ; 58(11): 1853-64, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19319529

Subject(s)

Antibodies, Monoclonal/pharmacology; Antineoplastic Agents/pharmacology; Carcinoma, Squamous Cell/drug therapy; ErbB Receptors/physiology; Head and Neck Neoplasms/drug therapy; Killer Cells, Natural/immunology; Polymorphism, Genetic; Receptors, IgG/genetics; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; Carcinoma, Squamous Cell/immunology; Cell Line, Tumor; Cetuximab; Cytokines/biosynthesis; ErbB Receptors/analysis; ErbB Receptors/genetics; Genotype; Head and Neck Neoplasms/immunology; Humans; Lymphocyte Activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Killer Cells, Natural / Carcinoma, Squamous Cell / Receptors, IgG / ErbB Receptors / Head and Neck Neoplasms / Antibodies, Monoclonal / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Immunol Immunother Journal subject: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: Germany

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