Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.

Manolopoulou, Marika; Guo, Qing; Malito, Enrico; Schilling, Alexander B; Tang, Wei-Jen

Manolopoulou, Marika; Guo, Qing; Malito, Enrico; Schilling, Alexander B; Tang, Wei-Jen.

Affiliation

Manolopoulou M; Ben-May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.

J Biol Chem ; 284(21): 14177-88, 2009 May 22.

Article in En | MEDLINE | ID: mdl-19321446

Subject(s)

Biocatalysis; Insulin/chemistry; Insulin/metabolism; Insulysin/metabolism; Protein Folding; Amino Acid Sequence; Crystallography, X-Ray; Cysteine; Humans; Insulysin/chemistry; Models, Molecular; Molecular Sequence Data; Mutant Proteins/chemistry; Mutant Proteins/metabolism; Peptide Fragments/chemistry; Protein Binding; Protein Structure, Secondary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Folding / Biocatalysis / Insulin / Insulysin Limits: Humans Language: En Journal: J Biol Chem Year: 2009 Document type: Article Affiliation country: United States Country of publication: United States

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