Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.

Debenham, John S; Madsen-Duggan, Christina B; Wang, Junying; Tong, Xinchun; Lao, Julie; Fong, Tung M; Schaeffer, Marie-Therese; Xiao, Jing Chen; Huang, Cathy C R-R; Shen, Chun-Pyn; Sloan Stribling, D; Shearman, Lauren P; Strack, Alison M; Euan Macintyre, D; Hale, Jeffrey J; Walsh, Thomas F

Debenham, John S; Madsen-Duggan, Christina B; Wang, Junying; Tong, Xinchun; Lao, Julie; Fong, Tung M; Schaeffer, Marie-Therese; Xiao, Jing Chen; Huang, Cathy C R-R; Shen, Chun-Pyn; Sloan Stribling, D; Shearman, Lauren P; Strack, Alison M; Euan Macintyre, D; Hale, Jeffrey J; Walsh, Thomas F.

Affiliation

Debenham JS; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

Bioorg Med Chem Lett ; 19(9): 2591-4, 2009 May 01.

Article in En | MEDLINE | ID: mdl-19328684

Subject(s)

Cannabinoid Receptor Agonists; Obesity/drug therapy; Pyrimidines/chemistry; Administration, Oral; Animals; Cannabinoids/chemistry; Chemistry, Pharmaceutical/methods; Drug Design; Humans; Inhibitory Concentration 50; Protein Structure, Tertiary; Rats; Receptor, Cannabinoid, CB1/agonists; Receptor, Cannabinoid, CB2/agonists; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Cannabinoid Receptor Agonists / Obesity Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2009 Document type: Article Affiliation country: United States Country of publication: United kingdom

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