Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.

Raguénez, Gilda; Mühlethaler-Mottet, Annick; Meier, Roland; Duros, Caroline; Bénard, Jean; Gross, Nicole

Raguénez, Gilda; Mühlethaler-Mottet, Annick; Meier, Roland; Duros, Caroline; Bénard, Jean; Gross, Nicole.

Affiliation

Raguénez G; Centre National de Recherche Scientifique, Unité Mixte de Recherche 8126, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France. raguenez@igr.fr

BMC Cancer ; 9: 97, 2009 Mar 30.

Article in En | MEDLINE | ID: mdl-19331667

Subject(s)

Apoptosis/drug effects; Caspase 8/metabolism; Fenretinide/pharmacology; Neuroblastoma/drug therapy; Xenograft Model Antitumor Assays/methods; Animals; Antineoplastic Agents/pharmacology; Blotting, Western; Bone Marrow/drug effects; Bone Marrow/metabolism; Bone Marrow/pathology; Caspase 8/genetics; Caspase Inhibitors; Cell Line, Tumor; Cell Survival/drug effects; Cysteine Proteinase Inhibitors/pharmacology; Drug Resistance, Neoplasm; Enzyme Activation/drug effects; Etoposide/pharmacology; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; Mice, Nude; Neoplasm Metastasis; Neuroblastoma/enzymology; Neuroblastoma/pathology; Reverse Transcriptase Polymerase Chain Reaction; TNF-Related Apoptosis-Inducing Ligand/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fenretinide / Apoptosis / Xenograft Model Antitumor Assays / Caspase 8 / Neuroblastoma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2009 Document type: Article Affiliation country: France Country of publication: United kingdom

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